
Christina Applegate hospitalized—words fans never want to hear, but they’ve become part of her reality since her multiple sclerosis (MS) diagnosis. Over the weekend, the Married… With Children and Dead to Me star rushed to the hospital after excruciating pain struck during a European vacation. Speaking on her Messy podcast, the 53-year-old assured listeners, “Things are messy, but I’m going to be OK,” even as she described her ordeal.
According to Fox News, this moment is another chapter in her ongoing battle. Applegate has long been open about her health struggles, often sharing her journey with honesty and humor. Her transparency recalls how other stars have invited fans into their private battles, offering inspiration through resilience and connection.
Christina Applegate Hospitalized After European Scare

Her discomfort began overseas. “I went to Europe to see family, and I was not feeling good the whole time I was there,” she explained. “I did everything I could to not throw up.” When she returned to Los Angeles, the pain grew unbearable. Determined to find answers, she demanded “every test” available.
The diagnosis came in the early hours of the morning: kidney infections that required intravenous antibiotics. “I’m like screaming,” she recalled. “It is the worst pain I’ve ever felt.” Even as she cracked jokes about the hospital stay, Christina Applegate admitted she sometimes collapsed in tears, leaning on nurses for support.
Christina Applegate Hospitalized Amid MS Journey
This scare is one of many since her 2021 MS diagnosis. Christina Applegate revealed she has been hospitalized “upwards of 30 times” over the last three years for vomiting, diarrhea, and intense abdominal pain. She explained that MS slows her organs, creating unpredictable and exhausting symptoms.
Still, she holds on to humor and hope. “The universe works in a really beautiful way. It listens to you—it really does. It also doesn’t give a s— if you say you want something, or you don’t want something,” she said. Her words, like her career, continue to resonate with fans who admire her courage through hardship.