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Christina Applegate Opens Up About Her Latest MS Flare: ‘Legs Are Busted’

by Ruth A • Published November 18, 2025

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Christina Applegate has never hidden the realities of her multiple sclerosis diagnosis. Since she revealed her condition in 2021, she has spoken openly, and her recent update added another honest look at life with Christina Applegate MS.

Parade explains how she continues to share difficult moments with courage. In her newest post, she described how stress sent her symptoms into a sudden flare, causing repeated falls and leaving her “legs busted.” She reminded followers that “when we get stressed or upset, our symptoms get worse,” a truth at the center of many Christina Applegate MS struggles.

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Christina Applegate’s MS Symptoms Intensify After Stress

 

 
 
 
 
 
View this post on Instagram
 
 
 
 
 
 
 
 
 
 
 

 

A post shared by Christina Applegate (@christinaapplegate)

 

In the video she shared, Applegate stood quietly before lifting her hand and giving the camera the finger. The moment captured her frustration more clearly than any caption could. She didn’t reveal what upset her, but the emotional weight of the week showed in her posture and her words. Her friend Sean Maguire hinted at the situation in the comments, promising support and criticizing the person who caused the distress. His message showed how closely her circle stands by her during every Christina Applegate MS flare.

Christina Applegate/Imagecollect

Fans reacted instantly. Many shared their own experiences with autoimmune issues, noting how quickly stress can trigger painful setbacks. Their encouragement filled the comment section with warmth. They understood exactly what she meant because they lived through the same swings and challenges.

Friends and Fans Rally Behind Her

iamseanmaguire/Instagram

More than 2,000 people offered support, including Jennifer Love Hewitt and Heather Dubrow. Their messages reminded her that she isn’t facing this journey alone. Lily Tomlin, Debbie Allen, and other familiar names added their voices as well. Each message showed how strongly people connect with Applegate’s honesty.

early signs of MS
Christina Applegate/Instagram

Her willingness to speak so directly about Christina Applegate’s MS continues to educate and comfort others with chronic illness. She gives people a clearer picture of how unpredictable and exhausting the condition can be. Even on her hardest days, she chooses to use her voice, and that choice gives strength to many who follow her story.

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About Ruth A

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